Publications

2025

Wisse, L. E. M., Wuestefeld, A., Murray, M.E., Jagust, W., La Joie R. Role of tau versus TDP-43 pathology on medial temporal lobe atrophy in aging and Alzheimer’s disease. Alzheimer’s & Dementia. https://doi.org/10.1002/alz.14582

2024

Wuestefeld, A., Pichet Binette, A., Berron, D., Baumeister, H., Van Westen, D., Stomrud, E., Mattsson-Carlgren, N., Strandberg, O., Smith, R., Palmqvist, S., Yushkevich, P. A., Hansson, O., Spotorno, N.*, Wisse, L. E. M.* Medial temporal lobe atrophy patterns in early-versus late-onset amnestic Alzheimer’s disease. Alzheimer’s Research & Therapy, https://doi.org/10.1186/s13195-024-01571-z.

Dong, M., Xie, L., Das, S. R., Wang, J., Wisse, L. E. M., De Flores, R., Wolk, D. A., Yushkevich, P. A., for the Alzheimer’s Disease NeuroImaging Initiative. Regional Deep Atrophy: a self-supervised learning method to automatically identify regions associated with Alzheimer’s disease progression from longitudinal MRI. Imaging Neuroscience, accepted. Preprint available: https://doi.org/10.48550/arXiv.2304.04673

Denning, A. E., Ittyerah, R., Levorse, L. M., Sadeghpour, N., Athlaye, C., Chung, E., Ravikumar, S., Dong, M., Duong, M. T., Lie, Y., Ilesanmi, A., Sreepada, L. P., Sabatini, P., Lowe, M., Bahena, A., Zablah, J., Watanabe, R., Kim, B., Hoejvang-Sourensen, M., Khandelwal, P., Hrybouski, S., Brown, C., Xie, S., De Flores, R., Robinson, J. L., Schuck, T., Ohm, D. T., Arezoumandan, S., Porta, S. A., Insausti, R. I., Wisse, L. E. M., Das, S. E., Irwin, D. J., Lee, E. B., Wolk, D. A., Yushkevich, P. A. Quantitative measurements of postmortem hippocampal tau and TDP-43 pathology are associated with in vivo medial temporal lobe cortical thickness. Acta Neuropathologica, https://doi.org/10.1007/s00401-024-02789-9.

Pichet Binette, A., Mammana, A., Wisse, L. E. M., Rossi, M., Mastenbroek, S., Strandberg, O., Smith, R., Mattsson-Carlgren, N., Janelidze, S., Palmqvist, S., ADNI, Parchi, P., Hansson, O. Associations between misfolded alpha-synuclein aggregates and Alzheimer’s disease pathology in vivo. Alzheimer’s & Dementia, https://doi.org/10.1002/alz.14225.

Canada, C., Mazloum-Farzaghi, N., Rådman, G., Adams, J. N., Bakker, A., Baumeister, H., Berron, D., Bocchetta, M., Carr, V., Dalton, M. A., De Flores, R., Kerezstes, A., La Joie, R., Mueller, S. G., Raz, N., Santini, T., Shaw, T., Stark, C. E. L., Tran, T., Wang, L., Wisse, L. E. M., Wuestefeld, A., Yushkevich, P. A., Olsen, R. K., Daugherty, A. M., on behalf of the Hippocampal Subfields Group. A (sub)field guide to quality control in hippocampal segmentation on high-resolution T2-weighted MRI. Human Brain Mapping, https://doi.org/10.1002/hbm.70004.

Wisse, L. E. M., Spotorno, N., Rossi, M., Grothe, M., Mammana, A., Tideman, P., Baiardi, S., Strandberg, O., Ticca, A., Van Westen, D., Mattsson-Carlgren, N., Palmqvist, S., Stomrud, E., Parchi, P., Hansson, O. The MRI signature of alpha-synuclein pathology in asymptomatic stages and in a memory clinic population. JAMA Neurology, https://doi.org/10.1001/jamaneurol.2024.2713.

Yushkevich, P. A., Ittyerah, R., Li, Y., Denning, A., Sadeghpour, N., Lim, S., McGrew, E., Xie, L., De Flores, R., Brown, C., Wisse, L. E. M., Wolk, D. A., Das, S. R. Morphometry of medial temporal lobe subregions using high-resolution T2-weighted MRI in ADNI3: Why, how and what’s next? Alzheimer’s & Dementia, https://doi.org/10.1002/alz.14161.

Khandelwal, P., Duong, M. T., Sadaghiani, S., Lim, S., Denning, A., Chung, E., Ravikumar, S., Arezoumandan, S., Peterson, C., Bedard, M., Capp, N., Ittyerah, R., Migdal, E., Choi, G., Kopp, E., Loja, B., Hasan, E., Li, J., Prabhakaran, K., Mizsei, G., Gabrielyan, M., Schuck, T., Robinson, J., Ohm, D., Lee, E. B., Trojanowski, J. Q., McMillan, C., Grossman, M., Irwin, D., Tisdall, M. D., Das, S. R., Wisse, L. E. M., Wolk, D. A., Yushkevich, P. A. Automated deep learning segmentation of high-resolution 7 tesla ex vivo MRI for quantitative analysis of structure-pathology correlations in neurodegenerative diseases. Imaging Neuroscience, https://doi.org/10.1162/imag_a_00171.

Ravikumar, S., Denning, A., Lim, S., Chung, E., Ittyerah, R., Wisse, L. E. M., Xie, L., Robinson, J. L., Schuck, T., Grossman, M., Lee, E. B., Tisdall, M. D., Prabhakaran, K., Detre, J. A., Mizsei, G., Artacho-Perula, E., Iniquez de Onzono Martin, M. M., Arroyo Jimenez, M. M., Munoz, M., Molina Romero, F. J., Marcos Rabal, M. P., Cebada Sanchez, S., Delgado Gonzalez, J. C., De la Rosa Prieto, C., Corcoles Parada, M., Irwin, D. J., Trojanowski, J. Q., Wolk, D. A., Insausti, R., Yushkevich, P. A. Postmortem imaging reveals patterns of medial temporal lobe vulnerability to tau pathology in Alzheimer’s disease. Nature Communications, 15, 4803. https://doi.org/10.1038/s41467-024-49205-0.

Giehl, K., Mutsaerts, H., Aarts, K., Barkhof, F., Caspers, S., Chetelat, G., Colin, M. E., Duzel, E., Frisoni, G., Ikram, A., Jovicich, J., Morbelli, S., Oertel, W., Paret, C., Perani, D., Repanas, K., Ritter, P., Segura, B., Wisse, L. E. M., De Witte, E., Cappa, S., Van Eimeren, T. Sharing brain imaging data in the Open Science era. How and why? The Lancet: Digital Health, 6 (7), E526-535. https://doi.org/10.1016/S2589-7500(24)00069-4.

Wuestefeld, A., Baumeister, H., Adams, J., De Flores, R., Hodgetts, C., Mazloum-Farzaghi, N., Olsen, R., Pulliyadi, V., Tran, T. T., Bakker, A., Canada, K., Carr, V., Dalton, M., Daugherty, A., La Joie, R., Raz, N., Start, C. E., Wang, L., Bedard, M., Buendia, E., Denning, A., Irwin, D. J., Ittyerah, R., Lee, E. B., Lim, S., Iniguez de Onzono Martin, M. M., Munoz, M., Robinson, J. L., Schuck, T., Trotman, W., Vela, A., Yushkevich, P., Amunts, K., Augustinack, J. C., Ding, S. L., Insausti, R., Kedo, O., Berron, D., **Wisse, L. E. M..** (2024). Comparison of histological delineation of medial temporal lobe cortices by four independent neuroanatomy laboratories. Hippocampus, 34 (5), 241-260. https://doi.org/10.1002/hipo.23602.

2023

Stouffer, K., Grande, X., Duezel, E., Johansson, M., Creese, B., Witter, M. P., Miller, I. M., Wisse, L. E. M., Berron, D. (2023). Amidst an amygdala renaissance in Alzheimer’s disease. Brain, awad411. https://doi.org/10.1093/brain/awad411

Lyu, X., Duong, M. T., Xie, L., De Flores, R., Richardson, H., Hwang, G., Wisse, L. E. M., DiCalogero, M., McMillan, C. T., Robinson, J. L., Xie, S. X., Trojanowski, J. Q., Grossman, M., Lee, E. B., Irwin, D. J., Dickerson, B. C., Davatzikos, C., Nasrallah, I. M., Yushkevich, P. A., Wolk, D. A., Das, S. R. (2023). Tau-neurodegeneration mismatch reveals vulnerability and resilience to comorbidities in Alzheimer’s continuum. Alzheimer’s & Dementia, 20(3), 1586-1600. https://doi.org/10.1002/alz.13559

Sadhagiani, S., Trotman, W., Lim, S. A., Chung, E., Ravikumar, S., Khandelwal, P., Prabhakaran, K., Mizsei, G., Ittyerah, R., Lavery, M. L., Ohm, D. T., Gabrielyan, M., Das, S. R., Schuck, T., Robinson, J. L., McMillan, C., Grossman, M., Lee, E. B., Detre, J. A., Xie, S. X., Trojanowski, J. Q., Tisdall, M. D., Wisse, L. E. M., Irwin, D. J., Wolk, D. A., Yushkevich, P. A. (2023). Associations of phosphorylated tau pathology with whole-hemisphere ex-vivo morphometry in 7 tesla MRI. Alzheimer’s & Dementia, 19(6), 2335-2364. https://doi.org/10.1002/alz.12884

Dominguez Perez, S., Phillips, J. S., Norise, C., Kinney, N. G., Vaddi, P., Halpin, A., Rascovsky, K., Irwin, D. J., McMillan, C. T., Xie, L., Wisse, L. E. M., Yushkevich, P. A., Kallogieri, D., Grossman, M., Cousins, K. A. Q. (2022). Neuropsychological and neuroanatomical features of patients with behavioral variant Alzheimer’s disease (AD): a comparison to behavioral variant frontotemporal dementia and amnestic AD groups. Journal of Alzheimer’s Disease, 89(2), 641-658. https://doi.org/10.3233/jad-215728

Hrybouski, S., Das, S. R., Xie, L., Wisse, L. E. M., Kelley, M., Lane, J., Sherin, M., DiCalogero, M., Nasrallah, I., Detre, J., Yushkevich, P. A., & Wolk, D. A. (2023). Aging and Alzheimer’s disease have dissociable effects on local and regional medial temporal lobe connectivity. Brain Communications, 5(5), fcad245. https://doi.org/10.1093/braincomms/fcad245

Wuestefeld, A., Pichet Binette, A., Berron, D., Spotorno, N., van Westen, D., Stomrud, E., … & Hansson, O. (2023). Age-related and amyloid-beta-independent tau deposition and its downstream effects. Brain, 146(8) 3192–3205. https://doi.org/10.1093/brain/awad135

Roh, H. S., Irwin, D. J., López, M. M., Martin, M. M. I. de O., Ittyerah, R., Lim, S., Bedard, M. L., Robinson, J. L., Schuck, T., Artacho-Pérula, E., Jiménez, M. del M. A., Rabal, M. P. M., Romero, F. J. M., Sánchez, S. C., González, J. C. D., Rosa-Prieto, C. de la, Parada, M. C., Lee, E. B., Ohm, D. T., … Chen, M. (2023). Integrating color deconvolution thresholding and weakly supervised learning for automated segmentation of neurofibrillary tangle and neuropil threads. Medical Imaging 2023: Digital and Computational Pathology, 12471, 1247103-1247103–1247106. https://doi.org/10.1117/12.2651848

Insausti, R., Insausti, A. M., López, M. M., Lorenzo, I. M., Arroyo-Jiménez, M. del M., Rabal, M. P. M., Rosa-Prieto, C. de la, Delgado-González, J. C., Etxeberria, J. M., Cebada-Sánchez, S., Raspeño-García, J. F., Onzoño, M. M. I. de, Romero, F. J. M., Benavides-Piccione, R., Tapia-González, S., Wisse, L. E. M., Ravikumar, S., Wolk, D. A., DeFelipe, J., … Artacho-Pérula, E. (2023). Ex vivo, in situ perfusion protocol for human brain fixation compatible with microscopy, MRI techniques, and anatomical studies. Frontiers in Neuroanatomy, 17, 1149674. https://doi.org/10.3389/fnana.2023.1149674

Xie, L., Das, S. R., Wisse, L. E. M., Ittyerah, R., Flores, R. de, Shaw, L. M., Yushkevich, P. A., Wolk, D. A., & Initiative, for the A. D. N. (2023). Baseline structural MRI and plasma biomarkers predict longitudinal structural atrophy and cognitive decline in early Alzheimer’s disease. Alzheimer’s Research & Therapy, 15(1), 79. https://doi.org/10.1186/s13195-023-01210-z

Xie, L., Wisse, L. E. M., Wang, J., Ravikumar, S., Khandelwal, P., Glenn, T., Luther, A., Lim, S., Wolk, D. A., & Yushkevich, P. A. (2023). Deep label fusion: A generalizable hybrid multi-atlas and deep convolutional neural network for medical image segmentation. Medical Image Analysis, 83, 102683. https://doi.org/10.1016/j.media.2022.102683

2022

Groot, C., Smith, R., Stomrud, E., Binette, A. P., Leuzy, A., Wuestefeld, A., Wisse, L. E. M., Palmqvist, S., Mattsson-Carlgren, N., Janelidze, S., Strandberg, O., Ossenkoppele, R., & Hansson, O. (2022). Phospho-tau with subthreshold tau-PET predicts increased tau accumulation rates in amyloid-positive individuals. Brain, 146(4), 1580–1591. https://doi.org/10.1093/brain/awac329

Zuroff, L., Wisse, L. E. M., Glenn, T., Xie, S. X., Nasrallah, I. M., Habes, M., Dubroff, J., Flores, R. de, Xie, L., Yushkevich, P., Doshi, J., Davatsikos, C., Shaw, L. M., Tropea, T. F., Chen-Plotkin, A. S., Wolk, D. A., Das, S., & Mechanic-Hamilton, D. (2022). Self- and Partner-Reported Subjective Memory Complaints: Association with Objective Cognitive Impairment and Risk of Decline. Journal of Alzheimer’s Disease Reports, 6(1), 411–430. https://doi.org/10.3233/adr-220013

Flores, R. de, Das, S. R., Xie, L., Wisse, L. E. M., Lyu, X., Shah, P., Yushkevich, P. A., & Wolk, D. A. (2022). Medial Temporal Lobe Networks in Alzheimer’s Disease: Structural and Molecular Vulnerabilities. The Journal of Neuroscience, 42(10), 2131–2141. https://doi.org/10.1523/jneurosci.0949-21.2021

Perez, S. D., Phillips, J. S., Norise, C., Kinney, N. G., Vaddi, P., Halpin, A., Rascovsky, K., Irwin, D. J., McMillan, C. T., Xie, L., Wisse, L. E. M., Yushkevich, P. A., Kallogjeri, D., Grossman, M., & Cousins, K. A. Q. (2022). Neuropsychological and Neuroanatomical Features of Patients with Behavioral/Dysexecutive Variant Alzheimer’s Disease (AD): A Comparison to Behavioral Variant Frontotemporal Dementia and Amnestic AD Groups. Journal of Alzheimer’s Disease, 89(2), 641–658. https://doi.org/10.3233/jad-215728

Vlegels, N., Ossenkoppele, R., Flier, W. M. van der, Koek, H. L., Reijmer, Y. D., Wisse, L. E. M., Biessels, G. J., & Initiative, A. D. N. (2022). Does Loss of Integrity of the Cingulum Bundle Link Amyloid-β Accumulation and Neurodegeneration in Alzheimer’s Disease? Journal of Alzheimer’s Disease, 89(1), 39–49. https://doi.org/10.3233/jad-220024

Wisse, L. E. M., Xie, L., Das, S. R., Flores, R. de, Hansson, O., Habes, M., Doshi, J., Davatzikos, C., Yushkevich, P. A., Wolk, D. A., & Initiative, A. D. N. (2022). Tau pathology mediates age effects on medial temporal lobe structure. Neurobiology of Aging, 109, 135–144. https://doi.org/10.1016/j.neurobiolaging.2021.09.017

2021

Ravikumar, S., Wisse, L. E. M., Lim, S., Ittyerah, R., Xie, L., Bedard, M. L., Das, S. R., Lee, E. B., Tisdall, M. D., Prabhakaran, K., Lane, J., Detre, J. A., Mizsei, G., Trojanowski, J. Q., Robinson, J. L., Schuck, T., Grossman, M., Artacho-Pérula, E., Martin, M. M. I. de O., … Yushkevich, P. A. (2021). Ex vivo MRI atlas of the human medial temporal lobe: characterizing neurodegeneration due to tau pathology. Acta Neuropathologica Communications, 9(1), 173. https://doi.org/10.1186/s40478-021-01275-7

Dong, M., Xie, L., Das, S. R., Wang, J., Wisse, L. E. M., deFlores, R., Wolk, D. A., Yushkevich, P. A., & Initiative, for the A. D. N. (2021). DeepAtrophy: Teaching a neural network to detect progressive changes in longitudinal MRI of the hippocampal region in Alzheimer’s disease. NeuroImage, 243, 118514. https://doi.org/10.1016/j.neuroimage.2021.118514

Yushkevich, P. A., López, M. M., Martin, M. M. I. de O., Ittyerah, R., Lim, S., Ravikumar, S., Bedard, M. L., Pickup, S., Liu, W., Wang, J., Hung, L. Y., Lasserve, J., Vergnet, N., Xie, L., Dong, M., Cui, S., McCollum, L., Robinson, J. L., Schuck, T., … Insausti, R. (2021). Three-dimensional mapping of neurofibrillary tangle burden in the human medial temporal lobe. Brain, 144(9), 2784–2797. https://doi.org/10.1093/brain/awab262

Berron, D., Vogel, J. W., Insel, P. S., Pereira, J. B., Xie, L., Wisse, L. E. M., Yushkevich, P. A., Palmqvist, S., Mattsson-Carlgren, N., Stomrud, E., Smith, R., Strandberg, O., & Hansson, O. (2021). Early stages of tau pathology and its associations with functional connectivity, atrophy and memory. Brain, 144(9), awab114-. https://doi.org/10.1093/brain/awab114

Hadar, P. N., Kini, L. G., Nanga, R. P. R., Shinohara, R. T., Chen, S. H., Shah, P., Wisse, L. E. M., Elliott, M. A., Hariharan, H., Reddy, R., Detre, J. A., Stein, J. M., Das, S., & Davis, K. A. (2021). Volumetric glutamate imaging (GluCEST) using 7T MRI can lateralize nonlesional temporal lobe epilepsy: A preliminary study. Brain and Behavior, 11(8), e02134. https://doi.org/10.1002/brb3.2134

Wisse, L. E. M., Ungrady, M. B., Ittyerah, R., Lim, S. A., Yushkevich, P. A., Wolk, D. A., Irwin, D. J., Das, S. R., & Grossman, M. (2021). Cross-sectional and longitudinal medial temporal lobe subregional atrophy patterns in semantic variant primary progressive aphasia. Neurobiology of Aging, 98, 231–241. https://doi.org/10.1016/j.neurobiolaging.2020.11.012

Wisse, L. E. M., Chételat, G., Daugherty, A. M., Flores, R. de, Joie, R. la, Mueller, S. G., Stark, C. E. L., Wang, L., Yushkevich, P. A., Berron, D., Raz, N., Bakker, A., Olsen, R. K., & Carr, V. A. (2021). Hippocampal subfield volumetry from structural isotropic 1 mm3 MRI scans: A note of caution. Human Brain Mapping, 42(2), 539–550. https://doi.org/10.1002/hbm.25234

Wisse, L. E. M., Flores, R. de, Xie, L., Das, S. R., McMillan, C. T., Trojanowski, J. Q., Grossman, M., Lee, E. B., Irwin, D., Yushkevich, P. A., Wolk, D. A., & Initiative, A. D. N. (2021). Pathological drivers of neurodegeneration in suspected non-Alzheimer’s disease pathophysiology. Alzheimer’s Research & Therapy, 13(1), 100. https://doi.org/10.1186/s13195-021-00835-2

Wisse, L. E. M., Ravikumar, S., Ittyerah, R., Lim, S., Lane, J., Bedard, M. L., Xie, L., Das, S. R., Schuck, T., Grossman, M., Lee, E. B., Tisdall, M. D., Prabhakaran, K., Detre, J. A., Mizsei, G., Trojanowski, J. Q., Artacho-Pérula, E., Martin, M. M. de I. de O., Arroyo-Jiménez, M. M., … Yushkevich, P. A. (2021). Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions. Acta Neuropathologica Communications, 9(1), 128. https://doi.org/10.1186/s40478-021-01225-3

McCollum, L. E., Das, S. R., Xie, L., Flores, R. de, Wang, J., Xie, S. X., Wisse, L. E. M., Yushkevich, P. A., Wolk, D. A., & Initiative, for the A. D. N. (2021). Oh brother, where art tau? Amyloid, neurodegeneration, and cognitive decline without elevated tau. NeuroImage: Clinical, 31, 102717. https://doi.org/10.1016/j.nicl.2021.102717